Lactobacillus reuteri Protectis reduced diarrhoea in children
(Thomson Reuters ONE) -
A double-blind, placebo-controlled study of 494 children showed that
supplementation of Lactobacillus reuteri Protectis significantly reduced
episodes of diarrhoea. Lactobacillus reuteri Protectis was particularly
effective in children with lower nutritional status. Another probiotic strain,
which was also tested, was without effect.
Study design
The six month long double-blind, placebo-controlled study was performed in
Indonesia and included 494 healthy children aged one to six years. The children
were randomly assigned to one of the following four groups: They were randomly
assigned to receive low-lactose milk with or without Lactobacillus casei 431 or
Lactobacillus reuteri DSM17938.
Outcome measures
Primary outcome of the study was number and duration of acute diarrhoeal
episodes. Diarrhoea was measured both according to the World Health
Organisation's definition of diarrhoea, >=3 loose/liquid stools in 24 hours, and
as incidence of all diarrhoea, >=2 loose/liquid stools in 24 hours. Secondary
outcome was number and duration of acute respiratory infections.
Significant results only with Lactobacillus reuteri Protectis
The results showed that the incidence of all diarrhoea episodes was
significantly reduced by 32 per cent in the group supplemented by Lactobacillus
reuteri Protectis compared to placebo. In children with lower nutritional status
(below median height and weight for the age group) Lactobacillus reuteri
Protectis had significant effect on both WHO defined and all episodes of
diarrhoea.
None of the other interventions showed any significant effects on either WHO
defined or all episodes of diarrhoea and none of the interventions affected
incidence or duration of acute respiratory infections. An additional finding was
significantly reduced antibiotic use in the Lactobacillus reuteri Protectis
supplemented children compared to those given placebo.
The study was conducted independently from BioGaia and the results were
announced in a press release by NIZO food research on 21 February 2012:
http://www.nizo.com/news/latest-news/56/bovee/
The study will be published in Journal of Pediatrics. Doctor Rina Agustina will
also present the results at the International Symposium of Probiotics and
Prebiotics in Pediatrics (IS3P) on 24 February 2012.
Diarrhoea and respiratory infections common
The prevalence of diarrhoea, acute respiratory infections as well as
malnutrition is high among children in low socioeconomic areas in Indonesia, as
well as in many other countries. In Indonesia diarrhoea contributes to 25 per
cent of all deaths among young children whereas acute respiratory infection has
a mortality rate of 16 per cent. Infection and malnutrition are interrelated and
strategies to increase resistance to infections in this population are needed.
- Especially children in these areas are exposed to a vicious circle of
undernutrition and frequent infection episodes. We know now that with the right
probiotics this negative spiral can be broken, says Ingeborg Bovee-Oudenhoven,
NIZO scientist and project leader, the Netherlands.
- These new and very positive results with Lactobacillus reuteri Protectis
confirm earlier studies with this probiotic strain in children with acute
diarrhoea. As the other probiotic tested in the study did not show any positive
effects, this strengthens the importance of using the right strain when choosing
a probiotic, says Peter Rothschild, President at BioGaia.
For additional information please contact
Peter Rothschild, President, telephone: +46 8 555 293 00
Eamonn Connolly, Senior Vice President Research, telephone: +46 8 555 293 00
BioGaia has published this information in accordance with the Swedish Securities
Market Act. The information was issued for publication on 22 February
2012, 09:30 am CET.
Press release 22 February 2012:
http://hugin.info/86913/R/1588105/498283.pdf
This announcement is distributed by Thomson Reuters on behalf of
Thomson Reuters clients. The owner of this announcement warrants that:
(i) the releases contained herein are protected by copyright and
other applicable laws; and
(ii) they are solely responsible for the content, accuracy and
originality of the information contained therein.
Source: BioGaia AB via Thomson Reuters ONE
[HUG#1588105]
Unternehmensinformation / Kurzprofil:
Datum: 22.02.2012 - 09:30 Uhr
Sprache: Deutsch
News-ID 117117
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