New research data on Basilea's novel oncology drug candidate presented
(Thomson Reuters ONE) -
Basilea Pharmaceutica AG / New research data on Basilea's novel oncology drug candidate presented processed and transmitted by Hugin AS. The issuer is solely responsible for the content of this announcement.
Basel, Switzerland, April 21, 2010 - New research data on Basilea's antitumor
drug candidate BAL101553 (prodrug of BAL27862) was presented at the American
Association of Cancer Research (AACR) Annual Meeting in Washington D.C. The
novel, intravenous and orally bioavailable small molecule disrupts the
intracellular microtubule network, a well established drug target in oncology.
The data confirm that the compound elicits a unique microtubule phenotype and
shows activity in a wide range of cancer types, including those resistant to
current treatment options.
Despite progress in the development of agents with antitumor activity, cancer
remains a significant challenge in healthcare. There is an increasing medical
need for novel agents with new mechanisms of action that overcome drug
resistance in cancer therapy.
BAL101553 (prodrug of BAL27862) - a unique mode of action
Microtubules are one of the components of the intracellular scaffold
(cytoskeleton). They are involved in many essential cellular processes and are a
well established target of anticancer drugs. In-vitro data generated in
collaboration with Prof. Diane Braguer's team, Institut national de la santé et
de la recherche médicale, Université de la Méditerranée, Marseille, France,
confirm that BAL27862 suppresses microtubule dynamics in living cancer cells.
Furthermore, the distinct microtubule phenotype induced by BAL27862 is
associated with an apparent severing of the microtubules leading to their
fragmentation (M.-A. Esteve et al., abstract #1977; selected for oral
presentation).
Studies from the same group and from the group of Prof. Branimir Sikic, Stanford
University, School of Medicine, California, USA (G. E. Duran et al., abstract
#4412), further demonstrate that BAL27862 has broad activity against a panel of
breast and ovarian cancer cell lines resistant to currently marketed
microtubule-targeted therapeutics. BAL27862 not only overcomes
P-glycoprotein-mediated resistance, but also resistance related to modifications
in the expression of proteins involved in tumor cell survival and microtubule
function, respectively. The distinct microtubule phenotype and anticancer
profile associated with BAL27862 supports evaluation in cancer patients with
treatment-refractory tumors.
Basilea also presented for the first time data characterizing BAL101553, a
prodrug of BAL27862 (J. Pohlmann et al., abstract #4419). The high water
solubility of BAL101553 allows intravenous administration in the absence of
solubilizing excipients which are known to be associated with adverse
side-effects in patients. This characteristic, together with a demonstration of
favorable pharmacokinetic properties and efficacy in animal tumor models,
confirms that BAL101553 has the potential to be conveniently administered as a
prodrug of the active compound BAL27862.
The phase I clinical development program to investigate the drug candidate in
humans is expected to be initiated in H2 2010.
+------------------------------------------------------------------------------+
|Abstracts on BAL27862/BAL101553 at the AACR 101(st) Annual Meeting |
| |
| * BAL27862: A unique microtubule-targeted drug that suppresses microtubule |
| dynamics, severs microtubules, and overcomes Bcl-2- and tubulin |
| subtype-related drug resistance - M.-A. Esteve, S. Honore, N. Mckay, F. |
| Bachmann, H. Lane, D. Braguer; abstract #1977 (selected for oral |
| presentation) |
| * In vitro activity of the novel tubulin active agent BAL27862 in MDR1(+) |
| and MDR1(-) human breast and ovarian cancer variants selected for |
| resistance to taxanes - G. E. Duran, H. Lane, F. Bachmann, B. I. Sikic; |
| abstract #4412 |
| * BAL101553: A highly soluble prodrug of the potent microtubule destabilizer|
| BAL27862 - J. Pohlmann, F. Bachmann, A. Schmitt-Hoffmann, G. Biringer, K. |
| Burger, C. Bucher, C. Schlaefle, J. Spickermann, R. Defoin, M. Pruschy, H.|
| Lane; abstract #4419 |
+------------------------------------------------------------------------------+
For further information please visit ww.aacr.org
About Basilea
Basilea Pharmaceutica Ltd. is headquartered in Basel, Switzerland, and listed on
the SIX Swiss Exchange (SIX:BSLN). Its integrated research and development
operations are currently focused on antibiotics and antifungals, as well as on
the development of dermatology and oncology drugs, all areas in which the
medical challenge of rising resistance or non-response to current treatment
options is commonly encountered. Basilea's products are targeted to satisfy high
medical and patient needs in the hospital and specialty care setting.
The company owns a broad and diversified portfolio. Basilea is marketing
Toctino® (alitretinoin), for the treatment of severe chronic hand eczema, in
Denmark, France, Germany, Switzerland and the United Kingdom. The drug is
approved in 11 additional European countries as well as in Canada and has been
recommended for approval in 11 further European countries. Furthermore, a phase
III clinical trial on alitretinoin for the treatment of severe chronic hand
eczema is ongoing in the U.S. Basilea has entered into a license, co-development
and co-promotion agreement with Astellas Pharma Inc. for its phase III compound
isavuconazole for the treatment of life-threatening invasive fungal infections
on a worldwide basis, including an option for Japan. Full rights to a third
late-stage product, ceftobiprole for the treatment of potentially
life-threatening resistant bacterial infections, will be transferred from Cilag
GmbH International, a Johnson & Johnson company, back to Basilea.
Disclaimer
This communication expressly or implicitly contains certain forward-looking
statements concerning Basilea Pharmaceutica Ltd. and its business. Such
statements involve certain known and unknown risks, uncertainties and other
factors, which could cause the actual results, financial condition, performance
or achievements of Basilea Pharmaceutica Ltd. to be materially different from
any future results, performance or achievements expressed or implied by such
forward-looking statements. Basilea Pharmaceutica Ltd. is providing this
communication as of this date and does not undertake to update any
forward-looking statements contained herein as a result of new information,
future events or otherwise.
For further information, please contact:
+----------------------------------------+-------------------------------------+
|Media Relations |Investor Relations |
+----------------------------------------+-------------------------------------+
|Adesh Kaul |Barbara Zink, Ph.D., MBA |
| | |
|Head Public Relations & |Head Corporate Development |
| | |
|Corporate Communications | |
| | |
|+41 61 606 1460 |+41 61 606 1233 |
| | |
|media_relations(at)basilea.com |investor_relations(at)basilea.com |
|
+----------------------------------------+-------------------------------------+
This press release can be downloaded fromwww.basilea.com
The press release can also be downloaded from the following link:
[HUG#1405990]
--- End of Message ---
Basilea Pharmaceutica AG
Grenzacherstrasse 487
P.O Box Basel Switzerland
Press release (PDF): http://hugin.info/134390/R/1405990/359677.pdf
Unternehmensinformation / Kurzprofil:
Datum: 21.04.2010 - 07:15 Uhr
Sprache: Deutsch
News-ID 19376
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