Quantity meets Quality
(firmenpresse) - The “classic” definition of High Throughput Oligos goes back to the needs for large numbers of mainly unmodified, moderately long standard oligos delivered in microtiter plate formats to suit the requirements of increasingly popular Genomic screening/microarray programs. Oligonucleotides consumed a prominent part of research “consumables” budgets due to huge order volumes, hence price and delivery time have been of the essence during the “Klondike Genomic Targets Rush” – the race for results entered a new velocity dimension.
In order to satisfy this demand, custom oligo houses were challenged to design production platforms enabling to manufacture oligonucleotides in a highly efficient way – efficient both in terms of output per time and cost per unit. Several concepts of synthesizing 48/96/384 ... oligos simultaneously/in one run have been realized. Some of these instruments became commercially available; some have been exclusively developed for inhouse/on-site use.
Cost efficient parallel synthesis of large numbers of individual molecules carries the immanent risk of losing quality without noticing unless the quality of high throughput synthesis products is stringently checked by suitable high throughput quality control measures. Again, cost and time constraints have to be carefully taken into consideration. 100% Mass Check of oligonucleotides became the method of choice for proving molecules´ integrity, bearing in mind its validity limitations with respect to desired full-length product´s relative purity from contaminants and absolute sequence integrity.
From the beginning, metabion recognized the risk of compromised quality coming along with mass production of oligonucleotides. Hence, metabion was determined to prove, that the slogan “quantity meets quality” comes alive by developing their own high throughput technology platform to produce HTOs (High Througput Oligos).
“Heart” of this platform is metabion´s inhouse developed 96-Parallel Synthesizer, called BH96 (“Blue Hedgehog” 96), which enables the company to produce high throughput-high quality oligos, a unique feature to be proud of. The uniqueness of our BH96 is convincingly reflected by the fact that metabion could protect the instrument´s technology by patent. Not only that the performance of metabion´s proprietary synthesis platform is outstandingly efficient in terms of produced quantity & quality, metabion has been the first company in Europe to introduce a 100% quality check by Maldi-ToF, and yet being able to offer HTOs at best value prices. metabion´s commitment to quality is further emphasized by its production procedures being ISO certified according to DIN EN 9001 and 13485.
Honoring customers´ demand for sizeable delivery amounts based on final yields in nmoles rather than abstract synthesis scales indicating to be expected OD260 values, metabion introduced a transparent and best price-performance scheme for its “classic” high throughput oligo portfolio, which comprises 3 standard yield scales and a fine selection of high throughput suitable single modifications delivered in various microtiter plate formats. metabion strongly believes in the saying “you get what you pay for”, and is determined to show, that one gets the best for one´s money (quantity & quality) at metabion.
Unternehmensinformation / Kurzprofil:
metabion is one of the globally leading suppliers of custom nucleic acids renowned for its focus on reliable supplies of consistently high quality products and services. Since 1998 metabion has been expanding its product portfolio from the production and analysis of a wide range of synthetic custom DNA and RNA oligonucleotides to the supply of standard life science products. Successfully translating highest quality standards into daily practice is the core of metabion´s business philosophy.
metabion GmbH/metabion international AG
Lena-Christ Strasse 44
D-82152 Planegg-Martinsried
E-Mail: info(at)metabion.com
Homepage: http://www.metabion.com
Tel: +49 (0)89 899 363 0
Fax: +49 (0)89 899 363 11
Datum: 02.09.2013 - 16:40 Uhr
Sprache: Deutsch
News-ID 292715
Anzahl Zeichen: 3355
contact information:
Contact person: Florian Preitauer
Town:
Planegg-Martinsried
Phone: +49 (0)89 899 363 0
Kategorie:
Pharmaceuticals & Biotech
Typ of Press Release: Produktinformation
type of sending: Veröffentlichung
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Die Pressemitteilung mit dem Titel:
"Quantity meets Quality"
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metabion GmbH/metabion international AG (Nachricht senden)
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