Annual Review for 2009
(Thomson Reuters ONE) -
Copenhagen, 6 May 2010
Announcement no. 4, 2010
Zealand Pharma A/S
("Zealand" or "the Company")
Annual Review for 2009
Zealand Pharma A/S, the biopharmaceutical company dedicated to the discovery and
development of innovative peptide-based drugs, today publishes an Annual Review
for the year ending 31 December 2009. For a copy of the full annual report and
accounts please go
to:http://www.zealandpharma.com/pdf/2010/Annual_report_2009_05_05_10.pdf
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|Highlights |
+------------------------------------------------------------------------------+
| * Licensing partner sanofi-aventis initiated and completed Phase I clinical|
| development with a combination of Lixisenatide (a Zealand Pharma invented|
| once-daily GLP-1 agonist) and sanofi-aventis's Lantus® (the world's|
| leading insulin brand) for Type 2 diabetes |
| * Initiation of pre-clinical trials with ZP2929 (a dual acting|
| Glucagon-GLP-1 agonist) for Type-2 diabetes and obesity |
| * Completion of Phase Ia study with ZP1848 (a GLP-2 agonist) for IBD|
| (inflammatory bowel disease) |
| * Initiation of a Phase Ib study with ZP1848 for Crohn's disease |
| * Finalization of the pre-clinical development programme with ZP2307 for|
| osteoporosis |
| * Positive data from Phase II clinical trials with ZP1480 for acute kidney|
| failure in cardiac surgery patients |
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|Post year-end highlights: |
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| * Sanofi-aventis announced positive results of the first, placebo-controlled|
| study of the GetGoal Phase III clinical trial program with Lixisenatide |
| * Sanofi-aventis announced that a Phase III program with the combination of|
| Lixisenatide/Lantus® is expected to commence in 2010 |
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Commenting on the Annual Review David Solomon, Chief Executive Officer and
President of Zealand Pharma, said: "2009 was a pivotal year for Zealand Pharma.
We focused the clinical pipeline and our research efforts to further develop new
and innovative peptide-based drug candidates for the treatment of metabolic,
gastrointestinal and cardiovascular diseases. As such, we reported the
accomplishment of significant development milestones throughout the year and are
enjoying this strong financial position. Zealand is becoming the world's
leading pure-play peptide company and we are uniquely positioned with a
late-stage portfolio of superior products serving disease areas of significant
unmet medical need and major market potential."
Financial Update
Zealand Pharma is a biopharmaceutical company investing in its own R&D with
revenues consisting of up-front payments and milestones received as part of
Zealand's partnering activities. As a result of the milestone payments received
in 2009 and further milestones expected in the coming year, Zealand is in a
strong financial position, enabling the Company to continue the clinical
development of its most advanced programs and to bring new drugs into clinical
development, either from Zealand's own innovative research pipeline or more
mature programs from external sources to supplement the traditional in-house
development path. Zealand's strong cash position also provides the Company with
a unique opportunity to pursue various strategic alliances.
Outlook
Zealand Pharma's goals and objectives are to focus on maturing the pipeline
rapidly and engaging in partnerships with pharmaceutical companies. In
parallel, Zealand will identify external development programmes in its core
therapy areas via creative in-licensing and partnering agreements. Zealand aims
to enhance company value in many ways and will continue to strengthen its
expertise in its core therapy areas which include diabetes, obesity,
cardiovascular and gastrointestinal diseases and metabolic organ failure.
Zealand will also broaden its knowledge and capabilities in all aspects of
peptide technology as it strives to become a global market leader in this
field.
For further information, please contact:
Zealand Pharma A/S
David Solomon, President and Chief Executive Officer
Zealand Pharma A/S, Smedeland 36, DK-2600 Copenhagen, Denmark
T +45 4328 1200 F +45 4328 1212 Einfo(at)zp.dk
www.zealandpharma.com
M:Communications
Mary-Jane Elliott / Emma Thompson
Tel: +44(0) 20 7920 2300
E-mail:Zealandpharma(at)mcomgroup.com
Notes for Editors
About Zealand Pharma A/S
Zealand Pharma A/S is a biopharmaceutical company dedicated to the discovery and
development of innovative peptide-based drugs. Zealand is a leader in peptide
drug development, a growing market with significant drug development activities
including treatment of diabetes, obesity, gastro-intestinal, metabolic and
cardiovascular diseases. All of Zealand's products target diseases and
indications with significant unmet clinical need and commercial potential.
Since 1999, Zealand's scientists have built a pipeline that includes five
compounds in clinical development, four of which have been out licensed, three
of these to major pharmaceutical companies (sanofi-aventis, Wyeth (now Pfizer)
and Helsinn Healthcare). All Zealand's compounds emerge from Zealand's own drug
discovery.
* Lixisenatide (AVE0010/ZP10), a pharmaceutical agent for the treatment of
T2DM, has been out-licensed to sanofi-aventis, the world's third largest
pharmaceutical corporation with a strong Diabetes franchise.
* ZP2929 is a novel, potent, long-acting dual Glucagon-GLP-1 agonist aiming to
provide a novel treatment option for people with T2DM and obesity. ZP2929
entered preclinical development in 2009 and has already demonstrated
improved glycaemic control as well as significant and sustained body weight
loss in pre-clinical pharmacology models.
* GAP-134/ZP1609, a gap junction modifier that prevents both ventricular and
atrial arrhythmias in animal models. With its oral formulation, the molecule
represents a novel paradigm for the prevention of chronic atrial
arrhythmias. US based pharmaceutical giant Wyeth Pharmaceutical (now Pfizer)
has finalized Phase I trials in the US.
* ZP1846 is an innovative treatment for prevention of chemotherapy-induced
diarrhoea, which may prevent discontinuation and dose modification during
cancer chemotherapy. A Phase I clinical trial has been conducted in the US.
The compound has been partnered with Helsinn Healthcare SA.
* ZP1848 is a novel treatment modality for the treatment of Inflammatory Bowel
Diseases (e.g. Crohn's Disease). The compound has completed Phase I clinical
development in the US with positive results.
* AP214/ZP1480 for Post-surgical Organ Failure, partnered with Action Pharma,
currently in clinical Phase II development.
In addition, Zealand has a rich and broad portfolio of pre-clinical projects
targeting a variety of disease areas, including osteoporosis and obesity-related
Diabetes.
Zealand Pharma A/S is based in Copenhagen. The Company's investors include,
Sunstone Capital, Allianz Private Equity, CDC Innovation, LD Pensions, Dansk
Erhvervsinvestering and LSP.
For more information please visit Zealand Pharma's web
site:www.zealandpharma.com
[HUG#1412351]
Press Release in PDF: http://hugin.info/136974/R/1412351/364584.pdf
Unternehmensinformation / Kurzprofil:
Datum: 06.05.2010 - 07:00 Uhr
Sprache: Deutsch
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