Nestlé scientists help to identify biomarkers for obesity-related health problems

Nestlé scientists help to identify biomarkers for obesity-related health problems

ID: 304139

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Nestlé scientists help to identify biomarkers for obesity-related health
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People with visceral obesity share a unique set of biomarkers that could one day
be used to identify individuals more likely to be at risk of developing obesity-
related health problems, a new study suggests.

Scientists from the Nestlé Research Center in Switzerland studied a group of
women with visceral obesity - where excess fat is concentrated around the
internal organs - and discovered they had a distinct 'metabolic signature' of
lipids and amino acids in common, as well as specific changes in gut microbial
activities.

The findings, published in the journal PLOS ONE, are part of an ongoing
scientific collaboration between Nestlé and General Electric to find efficient
and inexpensive methods of screening and monitoring body composition in
individuals.

Higher risk
"People who have visceral obesity are recognised as being at higher risk of
developing certain related illnesses," said François-Pierre Martin, the Nestlé
scientist who led the study.

"Finding minimally-invasive, fast and reliable biomarkers to screen people for
visceral obesity could help to monitor the effectiveness of different
therapies," he continued.

"In the future it could be an efficient and accessible way of helping to address
the burden of obesity-related problems such as insulin resistance, Type 2
diabetes and cardiovascular disease."

Imaging techniques
In the study, scientists monitored 40 obese but otherwise healthy women over a
two-week period at the out-patient obesity clinic of the University Hospital of
Lausanne, Switzerland.

They measured the women's body composition and distribution of fat tissue with




modern imaging techniques such as dual energy X-ray absorptiometry (DXA) and
computed tomography (CT), using technology provided by General Electric.

They also took blood and urine samples at regular intervals to monitor
individuals' metabolism.

Wider research
The study is part of a much wider programme of research conducted by Nestlé into
human metabolism as well as obesity and its related health problems.

Scientific work carried out by the company in these areas has included studies
examining the effects of various protein sources on energy metabolism, satiety
and glucose control, the complex signals sent by the gut to the brain, how to
improve glucose control for type two diabetes and the effect of chewing on
satiety.

Related information:
Nestlé Research Center
http://www.research.nestle.com/newscenter/news/nestl%c3%a9researcherssearchforno
velingredientstoimproveglucosecontrolfortype2diabetes

General Electric Research
http://ge.geglobalresearch.com/

University Hospital of Lausanne
http://www.chuv.ch/

Link to published study:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0073445

Read more stories about Nestlé research:
Nestlé research identifies metabolic signature for long life
http://www.nestle.com/Media/NewsAndFeatures/NRC-longevity-study

Nestlé expands research and development facilities in Singapore
http://www.nestle.com/Media/NewsAndFeatures/Nestle-expands-research-and-
development-facilities-in-Singapore

Nestlé opens most advanced laboratories in industry to study harmful pathogens
in food
http://www.nestle.com/Media/NewsAndFeatures/NRC-food-safety-labs


Media enquiries
Tel: +41 21 924 2200
Email: Nestlé Corporate Media Relations



This announcement is distributed by Thomson Reuters on behalf of
Thomson Reuters clients. The owner of this announcement warrants that:
(i) the releases contained herein are protected by copyright and
other applicable laws; and
(ii) they are solely responsible for the content, accuracy and
originality of the information contained therein.

Source: Nestlé S.A. via Thomson Reuters ONE
[HUG#1734500]




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Datum: 09.10.2013 - 10:10 Uhr
Sprache: Deutsch
News-ID 304139
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