Crucell Discovers Important New Antibody Against Influenza A
(Thomson Reuters ONE) -
Leiden, The Netherlands (July 7, 2011) - Dutch biopharmaceutical company Crucell
N.V. and The Scripps Research Institute today published an article in the
world's leading journal of original scientific research Science describing
Crucell's novel anti-influenza antibody CR8020 and how it neutralizes group 2
influenza A viruses. Attempts to isolate broadly neutralizing antibodies against
group 2 viruses have not been previously described. The broad neutralizing
ability of the CR8020 makes it a potentially groundbreaking therapy against
seasonal and pandemic flu.
"Influenza is an elusive enemy" said Jaap Goudsmit, Chief Scientific Officer at
Crucell. "The need for innovative approaches to the control of seasonal
influenza is highlighted by its death toll - estimated at 500,000 annually.
Having successfully discovered these antibodies, Crucell is determined to
develop an antibody therapy for flu."
In February 2009, Crucell and The Scripps Research Institute published a paper
in Science, reporting the discovery of a panel of human monoclonal antibodies
showing neutralizing activity against almost all influenza A group 1 viruses.
The most potent of these antibodies, called CR6261, prevents or cures influenza,
in animal tests, to deadly levels of the H5N1 and H1N1 viruses.
In this new study, Crucell reports that, by recognizing a novel conserved
epitope in the hemagglutinin stem, the antibody CR8020 shows broad neutralizing
activity against most influenza A group 2 viruses, including the H3N2 and H7N7
viruses, which cause severe human infection.
Crucell believes that a combination of these two antibodies may be sufficient to
neutralize most influenza A subtypes and, with that, enable the development of a
universal flu vaccine and a broad spectrum of antibody therapies.
Attempts to isolate broadly neutralizing antibodies against group 2 viruses have
not been previously described. Antibodies, such as CR6261 and CR8020, may
protect against essentially all influenza A viruses and would have undisputed
benefits for high-risk groups, such as the elderly and immunocompromised, and
for severe, life-threatening influenza infections.
Influenza and related medical complications result in an estimated number of
500,000 annual deaths worldwide. Every year more than 200,000 people in the
United States are hospitalized from flu complications and about 36,000 people
die from flu[1].
Currently, two main countermeasures are used against flu. Antivirals have been
widely used and proven to be quite effective. However, resistance to these
antivirals has reduced their effectiveness and mutations are widespread.
Vaccination is the other countermeasure. Each year circulating strains of
influenza virus subtypes, currently H1 and H3, change the composition of the
viral surface protein known as hemagglutinin by mutation. Consequently, if one
has had a vaccination against influenza this year, the antibodies produced by
the immune system will most likely not protect against next years' flu. If an
antibody was able to recognize an invariable structure in the hemagglutinin
protein, such an antibody could be applied for the prevention and therapy of
influenza caused by a wide variety of flu strains.
The unique property of the Crucell antibodies appears to be related to its
mechanism of action. The paper published in Science entitled "A Highly Conserved
Neutralizing Epitope on Group 2 Influenza A Viruses" shows the isolation and
characterization of a human monoclonal antibody CR8020 with broad neutralizing
activity against most group 2 viruses, including H3N2 and H7N7, which
sporadically cross from birds into humans and have the potential to develop into
a future pandemic.
"Influenza A viruses responsible for human pandemics have arisen from both group
1 and group 2 viruses." says Dr Robert Friesen, Crucell's Vice President
Preclinical and Clinical Research. "Therefore these results are a revolutionary
discovery for the potential development of an effective therapy of, and
prevention against, seasonal and pandemic influenza".
The results of this study will be presented by Dr Robert Friesen at the 7(th)
Annual European Antibody Congress taking place from November 29(th) till
December 1(st) in Geneva, Switzerland.
For both studies, Crucell collaborated with the Scripps Research Institute in
California, USA, which is a world leader in this type of molecular-level
research, the department of microbiology of the Univeristy of Hong Kong in Hong
Kong, and the Central Veterinary Institute of the University of Wageningen in
Lelystad, The Netherlands.
This project has been funded in whole or in part with Federal funds from the
National Institute of Allergy and Infectious Diseases, National Institutes of
Health, Department of Health and Human Services, under Contract No.
HHSN272200900060C.
[1] Source: Centers for Disease Control and Prevention.
Article reference: A Highly Conserved Neutralizing Epitope on Group 2 Influenza
A Viruses. Authors: Damian C. Ekiert,(1#) Robert H. E. Friesen,(2#) Gira
Bhabha,(1) Ted Kwaks,(2) Mandy Jongeneelen,(2) Wenli Yu,(1) Carla Ophorst,(2)
Freek Cox,(2) Hans J.W.M. Korse,(2) Boerries Brandenburg,(2) Ronald Vogels,(2)
Just P.J. Brakenhoff,(2) Ronald Kompier,(2) Martin H. Koldijk,(2) Lisette A.H.M.
Cornelissen,(3) Leo L. M. Poon,(4) Malik Peiris,(4) Wouter Koudstaal,(2*) Ian A.
Wilson,(1,5) and Jaap Goudsmit(2)
(1) Department of Molecular Biology, The Scripps Research Institute, 10550 North
Torrey Pines Road, La Jolla, CA 92037, USA; (2) Crucell Holland BV,
Archimedesweg 4-6, 2301 CA Leiden, The Netherlands; (3) Central Veterinary
Institute, Wageningen University, Lelystad, the Netherlands; (4) Department of
Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
Special Administrative Region, People's Republic of China; (5) The Skaggs
Institute for Chemical Biology, The Scripps Research Institute, 10550 North
Torrey Pines Road, La Jolla, CA 92037, USA. # These authors contributed equally
to this work.
About Crucell
Crucell N.V. is a global biopharmaceutical company focused on research
development, production and marketing of vaccines, proteins and antibodies that
prevent and/or treat infectious diseases. In 2010 alone, Crucell distributed
more than 105 million vaccine doses in more than 100 countries around the world.
Crucell is one of the major suppliers of vaccines to UNICEF and the developing
world. Crucell was the first manufacturer to launch a fully-liquid pentavalent
vaccine. Called Quinvaxem(®), this innovative combination vaccine protects
against five important childhood diseases. Over 200 million doses have been sold
since its launch in 2006 in more than 50 GAVI countries. With this innovation,
Crucell has become a major partner in protecting children in developing
countries. Other products in Crucell's core portfolio include a vaccine against
hepatitis B and a virosome-adjuvanted vaccine against influenza. Crucell also
markets travel vaccines, such as an oral anti-typhoid vaccine, an oral cholera
vaccine and the only aluminum-free hepatitis A vaccine on the market. Crucell
has a broad development pipeline, with several product candidates based on its
unique PER.C6(®) production technology. Crucell licenses its PER.C6(®)
technology and other technologies to the biopharmaceutical industry. Important
partners and licensees include DSM Biologics, sanofi-aventis, Novartis,
Pfizer/Wyeth, GSK, CSL and Merck & Co. Crucell is headquartered in Leiden, the
Netherlands, with offices in China, Indonesia, Italy, Korea, Malaysia, Spain,
Sweden, Switzerland, UK, the USA and Vietnam. Crucell employs over 1300 people.
Johnson & Johnson completed the tender offer for Crucell N.V. (Crucell) on
22(nd) February 2011 and declared the offer unconditional. As a result, Crucell
will now operate as the center for vaccines within the Johnson & Johnson
pharmaceuticals group.
For more information, please visit www.crucell.com.
Forward-looking statements
(This press release contains "forward-looking statements" as defined in the
Private Securities Litigation Reform Act of 1995. These statements are based on
current expectations of future events. If underlying assumptions prove
inaccurate or unknown risks or uncertainties materialize, actual results could
vary materially from the expectations and projections of Crucell N.V. and/or
Johnson & Johnson. Risks and uncertainties include, but are not limited to,
general industry conditions and competition; economic factors, such as interest
rate and currency exchange rate fluctuations; technological advances and patents
attained by competitors; challenges inherent in new product development,
including obtaining regulatory approvals; domestic and foreign health care
reforms and governmental laws and regulations; trends toward health care cost
containment; and increased scrutiny of the healthcare industry by government
agencies. A further list and description of these risks, uncertainties and
other factors can be found in Exhibit 99 of Johnson & Johnson's Annual Report on
Form 10-K for the fiscal year ended January 2, 2011. Copies of this Form 10-K,
as well as subsequent filings, are available online atwww.sec.gov, www.jnj.com
or on request from Johnson & Johnson. Neither Crucell N.V. nor Johnson &
Johnson undertake to update any forward-looking statements as a result of new
information or future events or developments.)
For further information please contact:
Crucell:
Oya Yavuz
Vice President Corporate Communications
Tel. +31 (0)71 519 7064
communications(at)crucell.com
www.crucell.com
PDF file:
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Source: Crucell N.V. via Thomson Reuters ONE
[HUG#1529318]
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Datum: 07.07.2011 - 20:01 Uhr
Sprache: Deutsch
News-ID 56236
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contact information:
Town:
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Kategorie:
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