Axelar reports good safety profile of AXL1717 in Phase I/II in cancer patients - Poster now published on the company's website
(Thomson Reuters ONE) -
STOCKHOLM, SWEDEN - September 26, 2011. Axelar AB, a Karolinska Development AB
portfolio company, today released results of the completed Phase I/II clinical
safety study for its drug candidate AXL1717 at the European Multidisciplinary
Cancer Congress (ESMO) meeting in Stockholm, Sweden. As reported earlier today,
all major objectives were met in the study and signs that suggest clinical
benefit were observed in some patients with non-small cell lung cancer. The
poster is now available on Axelar's and Karolinska Development's website.
For further information, please contact:
Johan Harmenberg, CEO, Axelar AB
Phone: +46 (0) 70 514 54 53, e-mail: johan.harmenberg(at)axelar.se
Torbjörn Bjerke, CEO, Karolinska Development AB
Phone: +46 (0)72 744 41 23, e-mail: torbjorn.bjerke(at)karolinskadevelopment.com
TO THE EDITORS
About Axelar
Axelar AB is a Swedish biotech company founded in 2003. The company is
developing insulin-like growth factor-1 (IGF-1) receptor inhibitors for
treatment of cancer and other diseases. Axelar is part of the Karolinska
Development portfolio of companies. www.axelar.se
About AXL1717
Axelar's lead compound, AXL1717 provides a novel potential treatment regimen for
a wide range of cancers. AXL1717 is the first targeted oral small-molecule
Insulin-like Growth Factor 1 (IGF-1) receptor inhibitor with no observable
effect on the closely-related insulin receptor. Most tumor cells are dependent
on the IGF-1 receptor signal pathway and the IGF-1 receptor is therefore
regarded as a promising target for cancer therapy. To date, there are no IGF-1
receptor inhibitor drugs on the market. AXL1717 has just completed its first-in-
man phase I/II clinical trial and the compound has already demonstrated a
superior preclinical efficacy against numerous tumors and an excellent
tolerability profile.
About Karolinska Development
Karolinska Development aims to create value for investors, patients, and
researchers by developing innovations from world class research into products
that can be sold or out-licensed with high returns. The business model is to:
SELECT the most commercially attractive medical innovations; DEVELOP these to
the stage where the greatest return on investment can be achieved; and
COMMERCIALIZE the innovations through the sale of companies or out licensing of
products. This will result in upfront payments, milestone payments and
royalties.
An exclusive deal flow agreement with Karolinska Institutet Innovations AB,
along with other cooperation agreements with leading Nordic universities,
delivers a continuous flow of innovations.
Karolinska Development's flexible exit strategy enables projects to be exited at
whichever stage of development offers the greatest return on investment, usually
after Phase II clinical trials have indicated the desired pharmaceutical effect
on patients - this being an important value enhancing step.
Today, the portfolio consists of over 35 projects at various stages, from
concept development to Phase II clinical trials, twelve projects are in clinical
trials. The portfolio is particularly strong in the areas of cancer,
dermatology, inflammation, cardiovascular disease, women's health and diseases
that affect the central nervous system. For more information, see
www.karolinskadevelopment.com
Poster:
http://hugin.info/143071/R/1549849/477009.pdf
Press release as PDF:
http://hugin.info/143071/R/1549849/477012.pdf
This announcement is distributed by Thomson Reuters on behalf of
Thomson Reuters clients. The owner of this announcement warrants that:
(i) the releases contained herein are protected by copyright and
other applicable laws; and
(ii) they are solely responsible for the content, accuracy and
originality of the information contained therein.
Source: Karolinska Development AB (publ) via Thomson Reuters ONE
[HUG#1549849]
Unternehmensinformation / Kurzprofil:
Datum: 26.09.2011 - 14:01 Uhr
Sprache: Deutsch
News-ID 69528
Anzahl Zeichen: 4431
contact information:
Town:
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Kategorie:
Business News
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"Axelar reports good safety profile of AXL1717 in Phase I/II in cancer patients - Poster now published on the company's website"
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